#SKIN SKEDADDLE SKIN#

#SKIN SKEDADDLE SKIN#

I think I may need to start an anti-aging regimen, and I’m wondering whether my sensitivity and dryness could mean bigger problems as my skin ages.” I use a mild or a sensitive-skin cleanser every morning (if I wash too often, my face dries out) and a rich moisturizer, and I occasionally do a vitamin C peel when my skin looks dull.

“I’m fairskinned, so I worry about sun damage. Her self-diagnosis: Dry and sensitive, with occasional redness. Here, a look at the good, the bad, and the likely-to-result-in-ugly.Įlizabeth Angell, 34, senior editor, Allure To find out just how far off base we can get - and how much better our skin could be - Allure sent six women on an undercover shopping mission, then asked top dermatologists to review the recommendations. In fact, 26 percent of women in a recent Olay survey admitted that they’ve broken out in a rash from a product that didn’t suit their skin type. “These variables can make the skin appear more dry or oily or sensitive than it really is - and using the wrong product can just make a problem worse.” Therefore, there is potential for significant absorption of DEET after the dermal application of commercial mosquito repellents, and ethanol, used as a solvent, may enhance the permeation of DEET.“There are all sorts of factors that can confuse the issue: climate, your time of the month, products you’re using,” says New York City dermatologist Doris Day. The Jss, P, and K values of DEET from the 30-45% ethanolic solutions were significantly higher than those from the 75-90% ethanolic solutions, while the tL and D values were similar for each solution. The total amount of DEET permeated from 30-45% ethanolic solutions at the end of 36 h was significantly higher than that from pure DEET and from the 60-90% ethanolic solutions. The tL and D values for each of the products were similar to that of pure DEET. Pure DEET exhibited the highest flux value of 63.20 +/- 24.52 micrograms/cm2-h, while Off Skintastic had the lowest value of 21.12 +/- 14.75 micrograms/cm2-h. The cumulative amount of DEET permeated can be ranked according to the following order: neat DEET (100%) = Everglades (95%) > Repel (52.25%) > Skedaddle (6.2%) = Off Skintastic (6.65%). Permeation parameters such as steady-state flux (Jss), lag time (tL), diffusion coefficient (D), permeability (P), and skin/ vehicle partition coefficient (K) were obtained from the permeation profiles in each case. Permeation studies of DEET from commercial mosquito repellents and from solutions containing various percentages of ethanol were conducted across human skin using an infinite dose technique with a Franz diffusion cell. The second objective was to study the effects of ethanol, the solvent for DEET, on the permeation of DEET and investigate its potential for enhancing the dermal absorption of DEET. The first objective of the present study was to evaluate the permeation characteristics of DEET from four commercial products, Everglades (95%), Repel Deerhunters (52.25%), Off Skintastic (6.65%), and Skedaddle (6.2%), as compared to pure DEET (approximately 100%). Many investigators have studied the dermal absorption of pure DEET however, there is only one report in the literature on the absorption of DEET from commercial mosquito repellents and the effect of concentration of DEET on its absorption through skin. N,N-Diethyl-m-toluamide (DEET), the active ingredient in many commercial mosquito repellents, is thought to be responsible for a wide range of local and systemic adverse reactions following its use.

Skin skedaddle